isirv

Q2 2024

Neuraminidase Inhibitors

Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023-February 2024…read more

Global emergence of neuraminidase inhibitor-resistant influenza A(H1N1)pdm09 viruses with I223V and S247N mutations: implications for antiviral resistance monitoring…read more

Impact of the H274Y Substitution on N1, N4, N5, and N8 Neuraminidase Enzymatic Properties and Expression in Reverse Genetic Influenza A Viruses…read more

Discovery and synthesis of novel benzoylhydrazone neuraminidase inhibitors…read more

Low antiviral resistance in Influenza A and B viruses isolated in Mexico from 2010 to 2023…read more

Baloxavir and Endonuclease Inhibitors

Comparative Effectiveness of Baloxavir Marboxil and Oseltamivir Treatment in Reducing Household Transmission of Influenza: A Post Hoc Analysis of the BLOCKSTONE Trial…read more

Discovery of baloxavir sodium as a novel anti-CCHFV inhibitor: Biological evaluation of in vitro and in vivo…read more

New Drug Discovery

Antiviral activity of adenoviral vector expressing human interferon lambda-4 against influenza virus…read more

Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract…read more

Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry…read more

Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways…read more

Spleen tyrosine kinase inhibitor R406 has both antiviral and anti-inflammatory effects on severe influenza A infection…read more

Host-directed antiviral strategy: The potential of SYK inhibitor R406 against influenza A virus infection…read more

Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core…read more

Broadly protective bispecific antibodies that simultaneously target influenza virus hemagglutinin and neuraminidase…read more

Clinical Trials and Modelling, Case Studies

Study on the clinical efficacy and safety of baloxavir marboxil tablets in the treatment of influenza A…read more

Pharmacoeconomic study of anti-influenza virus drugs in Japan based on a network meta-analysis…read more

A cost-effectiveness analysis of reduced viral transmission with baloxavir marboxil versus oseltamivir or no treatment for seasonal and pandemic influenza management in the United Kingdom…read more

Duration of fever in children infected with influenza A(H1N1)pdm09, A(H3N2) or B virus and treated with baloxavir marboxil, oseltamivir, laninamivir, or zanamivir in Japan during the 2012-2013 and 2019-2020 influenza seasons…read more

A noninferiority randomized open-label pilot study of 3- versus 7-day influenza postexposure prophylaxis with oseltamivir in hospitalized children…read more

Reviews & Commentary

Preclinical animal models to evaluate therapeutic antiviral antibodies…read more

Q1 2024

Neuraminidase Inhibitors

Inhibiting influenza virus transmission using a broadly acting neuraminidase that targets host sialic acids in the upper respiratory tract…read more

Recombinant A(H6N1)-H274Y avian influenza virus with dual drug resistance does not require permissive mutations to retain the replicative fitness in vitro and in ovo…read more

Baloxavir and Endonuclease Inhibitors

Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants…read more

Baloxavir marboxil use for critical human infection of avian influenza A H5N6 virus…read more

The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir…read more

Optimization and biological evaluation of l-DOPA derivatives as potent influenza PAN endonuclease inhibitors with multi-site binding characteristics…read more

Antivirals to prepare for surges in influenza cases: an economic evaluation of baloxavir marboxil for the Netherlands…read more

New Drug Discovery & Virucides

Identification of dihydroorotate dehydrogenase inhibitor, vidofludimus, as a potent and novel inhibitor for influenza virus…read more

Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results…read more

Influenza A virus resistance to 4'-fluorouridine coincides with viral attenuation in vitro and in vivo…read more

Discovery of cyperenoic acid as a potent and novel entry inhibitor of influenza A virus…read more

Clinical Trials & Case Studies

Outpacing antiviral resistance: new treatments for influenza virus infection…read more

Household Influenza Transmission and Healthcare Resource Utilization Among Patients Treated with Baloxavir vs Oseltamivir: A United States Outpatient Prospective Survey…read more

Clinical outcomes of baloxavir versus oseltamivir in immunocompromised patients…read more

Safety and efficacy of onradivir in adults with acute uncomplicated influenza A infection: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial…read more

Virological and clinical outcomes in outpatients treated with baloxavir or neuraminidase inhibitors for A(H3N2) influenza: A multicenter study of the 2022-2023 season…read more

Efficacy of Pharmacotherapy for Seasonal Influenza in Young and Middle-aged Adults: A Systematic Review and Network Meta-analysis…read more

Reviews & Commentary

Commentary: Randomized, placebo-controlled trial of antiviral treatment in patients hospitalized for influenza…read more

Antiviral News prepared by: Dr Jeremy C. Jones, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA